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How Vitamin D Affects Fatigue Among People with Multiple Sclerosis

  • December 19, 2023

According to the National Institutes of Health, 2.8 million people around the world are living with multiple sclerosis (MS), making it about 36 cases per 100,000 people. Since 2013, MS has been on the rise globally, and there are still gaps in understanding its full extent. In 75 countries, the yearly rate of new MS cases is 2.1 per 100,000, showing an ongoing challenge in diagnosis. On average, MS is diagnosed at age 32, and females are twice as likely as males to have it.

To better understand and address the growing challenges of this condition, let’s explore a recent scientific study that looked into the connection between Vitamin D supplementation and reducing fatigue in people with MS. This study was analyzed by our best nutrition and wellness coach. They have collected this data from five different trials, providing valuable insights into a potential way to manage fatigue in individuals dealing with MS.

So let’s give it a look:

Understanding Multiple Sclerosis

However, before we move further, let’s first understand: What is Multiple Sclerosis? It is a chronic autoimmune disease that affects the central nervous system, wherein the immune system is mistakenly attacked by the protective layer of nerve fibers known as myelin.

This results in communication disruptions between the brain and the rest of the body, leading to various symptoms such as fatigue, impaired coordination, and cognitive issues. Now, you must be thinking about the role of vitamin D in such a nervous system-related issue.

Keep reading, and you’ll get to know about it!

The Role of Vitamin D in Multiple Sclerosis

Vitamin D is often called “sunshine vitamin.” It is crucial in immune system regulation. Emerging evidence suggests a potential link between Vitamin D deficiency and the development or exacerbation of autoimmune diseases, including MS. Also, many studies prove that individuals with MS often exhibit lower levels of Vitamin D. However, more researchers have been exploring whether supplementation could offer therapeutic benefits, particularly in easing the burdensome symptom of fatigue.

It will be more evident when you read the study mentioned below!

The Scientist Study!

In a significant stride toward understanding this relationship, a study of randomized controlled trials was conducted. The study involved 345 participants, primarily aged between 25 and 41, with a predominant representation of women. All participants had been diagnosed with multiple sclerosis, with a majority exhibiting the relapsing-remitting form of the disease.

➔   Methodology of the Meta-Analysis


The meta-analysis amalgamated data from five distinct randomized controlled trials, each designed to evaluate the impact of vitamin D supplementation on fatigue levels in individuals with MS. Control groups in three studies received placebos, while one study compared vitamin D plus calcium against placebo plus calcium. A unique four-arm exercise study compared two intervention groups (vitamin D and vitamin D plus aerobic training) to a single control group (aerobic training plus placebo).

➔   Dosage and Duration of Vitamin D Supplementation


The vitamin D dosage in these trials varied from 280 IU per week (equivalent to 40 IU daily for six months) to a more intensive 50,000 IU per week, delivered weekly for eight weeks. The studies span from eight to 96 weeks, providing a comprehensive overview of the potential long-term effects of vitamin D supplementation on MS-related fatigue.

➔   Assessment of Fatigue

Various questionnaires were employed to measure the impact of vitamin D supplementation on fatigue, with the Fatigue Severity Scale (FSS) being the most commonly used tool. This standardized approach allowed for consistently evaluating fatigue levels across the diverse participant pool.

➔   Results of the Meta-Analysis


The meta-analysis yielded promising results, indicating a significant reduction in fatigue among participants supplemented with vitamin D compared to control groups. Even upon individual study removal from the pooled analysis, the positive effect persisted, underscoring the robustness of the findings. Notably, one study by Achiron et al. in 2014, comprising 158 participants, exhibited an exception to this trend, constituting approximately 46% of the pooled total.

The researchers classified two studies as having a high risk of bias, while three studies, including the above-mentioned Achiron et al. study, were deemed to have a low risk of bias. Notably, no publication bias was identified, bolstering the credibility of the meta-analysis results.

Incorporating Vitamin D into Your Daily Routine: A Strategy to Relieve Fatigue in Multiple Sclerosis

Based on the study of randomized controlled trials, the dosage of vitamin D varied across studies, ranging from 280 IU per week to 50,000 IU per week. While it’s essential to consult with a wellness coach before starting any supplementation regimen, this range provides a spectrum to consider.

➢   Understanding Optimal Dosages


For those aiming to ease fatigue associated with multiple sclerosis, starting with a moderate dose within this range may be a prudent approach. However, individual requirements can vary, emphasizing the importance of personalized guidance to determine the optimal dosage for your needs.

➢   Choosing the Right Form of Vitamin D


Vitamin D comes in different forms, with D2 and D3 being the most common. The studies did not explicitly focus on one form over the other. Still, existing research suggests that vitamin D3 is effective in maintaining and raising vitamin D levels in the body. Vitamin D3 might be a strategic choice when considering vitamin D supplements.

➢   Integrating Vitamin D-Rich Foods


Supplementation is not the sole avenue for increasing vitamin D levels. The meta-analysis did not specifically delve into dietary sources, but incorporating vitamin D-rich foods into your daily meals can contribute to overall nutritional well-being.

Fatty fish like salmon, tuna, and mackerel are excellent sources of vitamin D. Additionally, fortified foods such as milk, orange juice, and cereals can enhance your dietary intake. Integrating these foods into your meals supports vitamin D levels and provides essential nutrients to nourish your health.

➢   Sunlight Exposure and Its Role


While the meta-analysis primarily focused on supplementation, it’s crucial to recognize that the body can naturally produce vitamin D when exposed to sunlight. As advised by healthcare professionals, incorporating safe sun exposure into your routine can complement dietary and supplemental sources.

Individuals with MS should be cautious about heat sensitivity, a common symptom associated with the condition. Hence, it’s advisable to consult healthcare providers to determine a safe and effective balance between sunlight exposure and managing MS symptoms.

➢   Regular Monitoring and Professional Guidance


The studies highlighted in the meta-analysis underscore the potential benefits of vitamin D supplementation in relieving fatigue for individuals with multiple sclerosis. However, a key takeaway is the importance of personalized guidance and monitoring.

Regular check-ins with healthcare professionals can help assess the impact of supplementation on your vitamin D levels and overall well-being. These wellness coaching services providers can tailor recommendations based on your specific health profile, ensuring you get a practical approach to managing fatigue in multiple sclerosis.


In short, you now know how vitamin D deficiency relates to tiredness in people with multiple sclerosis. Well, there are some hopeful signs for managing these symptoms. The analysis of different studies strongly suggests that vitamin D can significantly decrease fatigue, bringing hope to those dealing with MS difficulties.

Therefore, adding vitamin D to your daily routine is essential. But make sure you know about what works best for you. This includes figuring out the right amount, choosing the best type of supplement, picking foods rich in vitamin D, getting some sunlight, and seeking professional advice.

So, visit Codex World today and find your nutrition and wellness coach who can guide you with the best diet, exercise, and overall wellness plan.

Sabin L
Founder & Owner

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Codex Team